Functional Insights into Protein Kinase A (PKA) Signaling from C. elegans

Functional Insights into Protein Kinase A (PKA) Signaling from C. elegans

Blog Article

Protein kinase A (PKA), which regulates a diverse set of biological functions downstream of cyclic AMP (cAMP), is a tetramer consisting of two catalytic subunits (PKA-C) and two regulatory subunits (PKA-R).When cAMP binds tonic shower cap the PKA-R subunits, the PKA-C subunits are released and interact with downstream effectors.In Caenorhabditis elegans (C.elegans), PKA-C and PKA-R are encoded by kin-1 and kin-2, respectively.

This review focuses on the contributions of work in C.elegans to our understanding of the many roles of PKA, including contractility and oocyte maturation in the reproductive system, lipid metabolism, knowall.blog physiology, mitochondrial function and lifespan, and a wide variety of behaviors.C.elegans provides a powerful genetic platform for understanding how this kinase can regulate an astounding variety of physiological responses.